Model portefeuille
Rendement portefeulle
+12.035 %

Rendement AEX
+33.325 %

Startdatum
01-01-2009

Startwaarde portefeuille € 74082.37

Startwaarde AEX
€ 245.94


Laatste update:
29-01-2010

Not so tasty: How obesity dulls the sense of taste, prompting overeating

Alleen voor leden beschikbaar, wordt daarom gratis lid!

Overig advies 21/03/2018 14:54
21 Mar 2018 --- A new study in PLOS Biology by researchers at Cornell University has shown that inflammation, driven by obesity, can reduce the number of taste buds on the tongues of mice. According to the researchers, the data suggests that gross adiposity stemming from chronic exposure to a high-fat diet is associated with an inflammatory response causing a disruption in the balancing mechanisms of taste bud maintenance and renewal. The reduction of taste buds can cause further overeating.

A taste bud comprises of approximately 50 to 100 cells of three major types, each with different roles in sensing the five primary tastes (salt, sweet, bitter, sour and umami).

Taste bud cells turn over quickly, with an average lifespan of just ten days. To explore changes in taste buds in obesity, the authors fed mice either a normal diet made up of 14 percent fat, or an obesogenic diet containing 58 percent fat.

After eight weeks, the mice fed the obesogenic diet weigh about one-third more than those receiving normal chow. But strikingly, the obese mice had about 25 percent fewer taste buds than the lean mice, with no change in the average size or the distribution of the three cell types within individual buds.

The turnover of taste bud cells normally arises from a balanced combination of programmed cell death (a process known as apoptosis) and generation of new cells from special progenitor cells. However, the researchers observed that the rate of apoptosis increased in obese mice, whereas the number of taste bud progenitor cells in the tongue declined, likely explaining the net decline in the number of taste buds.

Mice that were genetically resistant to becoming obese did not show these effects, even when fed a high-fat diet, implying that they are due not to the consumption of fat per se, but rather the accumulation of fatty tissue (adipose).

Obesity is known to be associated with a chronic state of low-grade inflammation, and adipose tissue produces pro-inflammatory cytokines – molecules that serve as signals between cells – including one called TNF-alpha. The authors found that the high-fat diet increased the level of TNF-alpha surrounding the taste buds; however, mice that were genetically incapable of making TNF-alpha had no reduction in taste buds, despite gaining weight. Conversely, injecting TNF-alpha directly into the tongue of lean mice led to a reduction in taste buds, despite the low level of body fat.

“These data together suggest that gross adiposity stemming from chronic exposure to a high-fat diet is associated with a low-grade inflammatory response causing a disruption in the balancing mechanisms of taste bud maintenance and renewal,” Dando says. “These results may point to novel therapeutic strategies for alleviating taste dysfunction in obese populations.”



Beperkte weergave !
Leden hebben toegang tot meer informatie! Omdat u nog geen lid bent of niet staat ingelogd, ziet u nu een beperktere pagina. Wordt daarom GRATIS Lid of login met uw wachtwoord


Copyrights © 2000 by XEA.nl all rights reserved
Niets mag zonder toestemming van de redactie worden gekopieerd, linken naar deze pagina is wel toegestaan.


Copyrights © DEBELEGGERSADVISEUR.NL